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LL-37

LL-37

LL-37 是一种具有血管生成活性的抗菌肽。它对应于人导管素抗菌蛋白 hCAP18/LL-37 的 C 末端序列 (134-170),并通过蛋白水解加工从 hCAP18/LL-37 释放到细胞外。hCAP18/LL-37 是先天免疫系统的效应子,在白细胞和上皮细胞中表达,在炎症和损伤相关的地方上调。可以证明 hCAP18/LL-37 在一系列乳腺癌中的过度表达。LL-37 已被建议部分通过甲酰肽受体样 1 (FPRL1) 刺激上皮细胞增殖,因为用百日咳毒素阻断该受体可使 LL-37 的增殖作用降低约 50%。 序列: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg- Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH(三氟乙酸盐) 单字母序列: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 参考文献: Z.Oren et al., Biochem. J., 341, 501 (1999) R.Koczulla et al., J. Clin. Invest., 111, 1665 (2003) R.Shaykhiev et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L842 (2005) J.D.Heilborn et al., Int. J. Cancer, 114, 713 (2005) G.H. Gudmundsson et al., Eur. J. Biochem., 238, 325 (1996) R. Bals et al., Cell. Mol. Life Sci., 60, 711 (2003) M. Zanetti, J. Leukoc. Biol., 75, 39 (2004) P.T. Liu et al., Science, 311, 770 (2006) R. Lande et al., Nature, 449, 564 (2007) P.Y. Ong et al., New Engl. J. Med., 347, 1151 (2002) D.W. Hoskin et al., Biochim. Biophys. Acta, 1778, 357 (2008) Y.P. Lai et al., Trends Immunol., 30, 131 (2009) M.F. Burton et al., Nat. Prod. Rep., 26, 1572 (2009) PRODUCT CITATIONS: Fumakia, Miral D., and Emmanuel Abraham Ho. Molecular Pharmaceutics (2016).» Chen, Yufei, Sidi Yang, and Emmanuel A. Ho. Chromatographia 77.23-24 (2014): 1713-1720.» Srakaew, Nopparat, et al. Human Reproduction 29.4 (2014): 683-696.» Choi, Ka-Yee G., Scott Napper, and Neeloffer Mookherjee. Immunology 143.1 (2014): 68-80.» Mookherjee, Neeloffer. U.S. Patent Application No. 13/581,227 (2013).» Madera, Laurence. Electronic Theses and Dissertations (ETDs) 2008+ (2012).» Madera, Laurence, and Robert EW Hancock. Journal of Innate Immunity 4.5-6 (2012): 553-568.» Walters, S. M., et al. Peptides 31.9 (2010): 1649-1653.» Dixon, Douglas R., et al. Peptides 30.12 (2009): 2161-2167.»

产品货号: KS021002

序列:LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH (trifluoroacetate salt)

纯度:≥95%

分子式:C<sub>205</sub>H<sub>340</sub>N<sub>60</sub>O<sub>53</sub>

分子式: C205H340N60O53

分子量:4493.27

外观:冻干粉末

CAS#:154947-66-7

储存条件:Store at -20°C or -80°C

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描述:

LL-37 是一种具有血管生成活性的抗菌肽。它对应于人导管素抗菌蛋白 hCAP18/LL-37 的 C 末端序列 (134-170),并通过蛋白水解加工从 hCAP18/LL-37 释放到细胞外。hCAP18/LL-37 是先天免疫系统的效应子,在白细胞和上皮细胞中表达,在炎症和损伤相关的地方上调。可以证明 hCAP18/LL-37 在一系列乳腺癌中的过度表达。LL-37 已被建议部分通过甲酰肽受体样 1 (FPRL1) 刺激上皮细胞增殖,因为用百日咳毒素阻断该受体可使 LL-37 的增殖作用降低约 50%。 序列: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg- Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH(三氟乙酸盐) 单字母序列: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 参考文献: Z.Oren et al., Biochem. J., 341, 501 (1999) R.Koczulla et al., J. Clin. Invest., 111, 1665 (2003) R.Shaykhiev et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L842 (2005) J.D.Heilborn et al., Int. J. Cancer, 114, 713 (2005) G.H. Gudmundsson et al., Eur. J. Biochem., 238, 325 (1996) R. Bals et al., Cell. Mol. Life Sci., 60, 711 (2003) M. Zanetti, J. Leukoc. Biol., 75, 39 (2004) P.T. Liu et al., Science, 311, 770 (2006) R. Lande et al., Nature, 449, 564 (2007) P.Y. Ong et al., New Engl. J. Med., 347, 1151 (2002) D.W. Hoskin et al., Biochim. Biophys. Acta, 1778, 357 (2008) Y.P. Lai et al., Trends Immunol., 30, 131 (2009) M.F. Burton et al., Nat. Prod. Rep., 26, 1572 (2009) PRODUCT CITATIONS: Fumakia, Miral D., and Emmanuel Abraham Ho. Molecular Pharmaceutics (2016).» Chen, Yufei, Sidi Yang, and Emmanuel A. Ho. Chromatographia 77.23-24 (2014): 1713-1720.» Srakaew, Nopparat, et al. Human Reproduction 29.4 (2014): 683-696.» Choi, Ka-Yee G., Scott Napper, and Neeloffer Mookherjee. Immunology 143.1 (2014): 68-80.» Mookherjee, Neeloffer. U.S. Patent Application No. 13/581,227 (2013).» Madera, Laurence. Electronic Theses and Dissertations (ETDs) 2008+ (2012).» Madera, Laurence, and Robert EW Hancock. Journal of Innate Immunity 4.5-6 (2012): 553-568.» Walters, S. M., et al. Peptides 31.9 (2010): 1649-1653.» Dixon, Douglas R., et al. Peptides 30.12 (2009): 2161-2167.»

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  • 内容
    • 商品名称: LL-37
    • 产品货号: KS021002
    • 序列: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH (trifluoroacetate salt)
    • 纯度: ≥95%
    • 分子式: C<sub>205</sub>H<sub>340</sub>N<sub>60</sub>O<sub>53</sub>
    • 分子量: 4493.27
    • 外观: 冻干粉末
    • CAS#: 154947-66-7
    • 储存条件: Store at -20°C or -80°C
    • 1mg:

    LL-37 是一种具有血管生成活性的抗菌肽。它对应于人导管素抗菌蛋白 hCAP18/LL-37 的 C 末端序列 (134-170),并通过蛋白水解加工从 hCAP18/LL-37 释放到细胞外。hCAP18/LL-37 是先天免疫系统的效应子,在白细胞和上皮细胞中表达,在炎症和损伤相关的地方上调。可以证明 hCAP18/LL-37 在一系列乳腺癌中的过度表达。LL-37 已被建议部分通过甲酰肽受体样 1 (FPRL1) 刺激上皮细胞增殖,因为用百日咳毒素阻断该受体可使 LL-37 的增殖作用降低约 50%。 序列: H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg- Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH(三氟乙酸盐) 单字母序列: LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES 参考文献: Z.Oren et al., Biochem. J., 341, 501 (1999) R.Koczulla et al., J. Clin. Invest., 111, 1665 (2003) R.Shaykhiev et al., Am. J. Physiol. Lung Cell. Mol. Physiol., 289, L842 (2005) J.D.Heilborn et al., Int. J. Cancer, 114, 713 (2005) G.H. Gudmundsson et al., Eur. J. Biochem., 238, 325 (1996) R. Bals et al., Cell. Mol. Life Sci., 60, 711 (2003) M. Zanetti, J. Leukoc. Biol., 75, 39 (2004) P.T. Liu et al., Science, 311, 770 (2006) R. Lande et al., Nature, 449, 564 (2007) P.Y. Ong et al., New Engl. J. Med., 347, 1151 (2002) D.W. Hoskin et al., Biochim. Biophys. Acta, 1778, 357 (2008) Y.P. Lai et al., Trends Immunol., 30, 131 (2009) M.F. Burton et al., Nat. Prod. Rep., 26, 1572 (2009) PRODUCT CITATIONS: Fumakia, Miral D., and Emmanuel Abraham Ho. Molecular Pharmaceutics (2016).» Chen, Yufei, Sidi Yang, and Emmanuel A. Ho. Chromatographia 77.23-24 (2014): 1713-1720.» Srakaew, Nopparat, et al. Human Reproduction 29.4 (2014): 683-696.» Choi, Ka-Yee G., Scott Napper, and Neeloffer Mookherjee. Immunology 143.1 (2014): 68-80.» Mookherjee, Neeloffer. U.S. Patent Application No. 13/581,227 (2013).» Madera, Laurence. Electronic Theses and Dissertations (ETDs) 2008+ (2012).» Madera, Laurence, and Robert EW Hancock. Journal of Innate Immunity 4.5-6 (2012): 553-568.» Walters, S. M., et al. Peptides 31.9 (2010): 1649-1653.» Dixon, Douglas R., et al. Peptides 30.12 (2009): 2161-2167.»

关键词:

肽类药物,创新药物,肽类种子库

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